In vitro efficacy of cinnamon derived copper nanoconjugates against drug-resistant and sensitive strains of Mycobacterium tuberculosis

Volume 8, Issue 4, August 2024     |     PP. 139-153      |     PDF (432 K)    |     Pub. Date: August 16, 2024
DOI: 10.54647/isss120357    38 Downloads     2727 Views  

Author(s)

Pratheeka Rajan, PG & Research Department of Biotechnology Women’s Christian College 51 College Road, Subha Rao Avenue, Chennai – 6 , Tamil Nadu, India
Anchana Devi, PG & Research Department of Biotechnology Women’s Christian College 51 College Road, Subha Rao Avenue, Chennai – 6 , Tamil Nadu, India
Angayarkanni B, Department of Bacteriology ICMR- National institute for Research in Tuberculosis Chennai, Tamil Nadu, India
Azger Dusthackeer, Department of Bacteriology ICMR- National institute for Research in Tuberculosis, Chennai, Tamil Nadu, India
Priya R Iyer, PG & Research Department of Biotechnology Women’s Christian College 51 College Road, Subha Rao Avenue, Chennai – 6 , Tamil Nadu, India

Abstract
Background: Tuberculosis is a chronic infectious disease that is caused by Mycobacterium tuberculosis. In the treatment forefront there are drugs like rifampicin, pyrazinamide, isoniazid that are used. However, long-term use of these medications causes multidrug-resistant bacteria and drug-induced liver damage. In the present study, the effect of the test drug (nano-conjugate) synthesized from Cinnamon was tested for its anti-tuberculosis activity by broth microdilution method. In addition, its efficacy was further tested against multi drug resistant and sensitive strains of tuberculosis.
Results: The initial Minimum Inhibitory Concentration of the nanoconjugate was found to be 250 μg/ml against the M. tuberculosis strain H37Rv. Furthermore, it was effective against the sensitive and resistant strains of tuberculosis with a MIC of 250 and 500 μg/ml respectively.
Conclusion: The current investigation found a prospective anti-tuberculosis drug candidate which could aid in the rational creation of more potent medications against tuberculosis.

Keywords
Tuberculosis, nanodrug, Minimum Inhibitory Concentration

Cite this paper
Pratheeka Rajan, Anchana Devi, Angayarkanni B, Azger Dusthackeer, Priya R Iyer, In vitro efficacy of cinnamon derived copper nanoconjugates against drug-resistant and sensitive strains of Mycobacterium tuberculosis , SCIREA Journal of Information Science and Systems Science. Volume 8, Issue 4, August 2024 | PP. 139-153. 10.54647/isss120357

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